Measles, measles, and more measles. I know, it seems like all I’m writing about. I’ve been doing media interviews for weeks now on measles infections and there doesn’t seem to be a slowdown yet. As it stands, there are currently 839 measles cases in the U.S. and children under age 5 years old account for about half of the cases. The vast majority of cases are in those who are unvaccinated. I’ve been asked: “Is the situation improving?” The answer is…no…sadly. The 75 new cases this week are a higher bump than in the previous two weeks, when about 60 additional cases were reported each week. Measles is wildly contagious. It spreads when a person infected with the measles virus breathes, coughs, or sneezes. You can catch measles just by being in a room where a person with measles has been, up to 2 hours after that person is gone.
The great news, as always, is that we have a vaccine for this! We can prevent this from ever happening in the first place! Parents and children who are immunized are well protected and don’t need to worry right now.
This is the greatest number of cases reported in the U.S. since measles was eliminated from this country in 2000. The high number of cases in 2019 is primarily the result of a few large outbreaks – one in Washington State and two large outbreaks in New York that started in late 2018. New York has the biggest outbreak, accounting for almost 700, or more than 80%, of the cases nationwide. There are 4 new confirmed measles cases in western Washington involving people who spent time at the Seattle-Tacoma International Airport. If you’re concerned you could have been exposed, talk with your doctor.
If you wonder if you’re up-to-date on MMR vaccines talk with your doc about a blood test to prove your immunity or repeating/starting the MMR shot. Here’s info on MMR shot.
Perhaps one shining light that has come from this awful outbreak is that new laws are being passed to increase safety in our schools and communities. Last Friday, in my home state, Washington’s governor signed a law that says parents with children heading to daycare or school will no longer be able to claim personal or philosophical objections to the measles, mumps and rubella vaccine — schools will increasingly be the LAST place your child would ever get exposed to measles. Big win!
Children Too Young To Be Immunized:
The question I may have received the most is surrounding protection for babies too young to be immunized. Can I travel with my baby? Should I avoid the grocery store? Can they go on playdates? My answer is a little complicated — but yes, even during this outbreak we can live mostly as we normally do. You do not need to hunker down at home.
I hate that I can’t completely say infants are perfectly safe during an outbreak. Infants are a vulnerable population during a measles outbreak …however, newborns are well protected by the antibodies their mom passed onto them. With each month after birth, infants gradually lose some of those maternal antibodies and they become more at-risk if, in the rare case, they are exposed. Breastmilk has immune protection but it isn’t thought to be enough to protect an infant alone.
Measles is wildly contagious and during an outbreak, it can spread, especially to older infants and children who aren’t vaccinated yet. The good news is that risk of exposure outside of areas during an outbreak is low (more than 90% of us won’t get measles because we’re vaccinated so we also won’t also spread it to your baby). If you don’t live in an area where there is an active outbreak, I would say, yes, take your baby grocery shopping and go on your vacation. If you are traveling internationally, and your baby is 6 months of age, we recommend they go get the MMR vaccine a little early (typically given at 12 months of age). Here’s some more information I wrote when the outbreaks started about infants and young children.
What About Infants 6-12 Months Who Live Where Outbreaks Are Occurring?
You can always talk with your own pediatrician about this. The short answer is there is no need to accelerate the vaccine schedule for your baby (no need to get an “early shot” of MMR) right now in the US and in fact, there may be more reason not to. Here’s how the state of Washington Dept of Health explains it that I’ve just learned:
“Although there is urgency to protect the public, there is currently no Washington State Public Health recommendation to immunize infants below the age of 12 months earlier than the recommended schedule. Although the Advisory Committee for Immunization Practice (ACIP) recommendations include vaccinations for children in this age group related to international travel and for prophylaxis within three days of exposure to measles, there are risks associated with receiving MMR vaccine under the age of 12 months. A review of Washington Immunization Information System (WA IIS) indicates a higher number than usual children below the age of 12 months received the MMR vaccine in January and February 2019. The vast majority of these doses were not given as prophylaxis in the three days following an exposure to a measles case, and only a few are likely to be related to international travel. This is of concern because administration of MMR below the age of 12 months has been associated with blunting of the immune response to subsequent doses administered according to the routine ACIP recommendations.”
This means that there is no need to get the vaccine early (in a healthy 8 month-old baby living in Seattle, for example) as the early immunization may make the later immunization less effective and durable. Because the risk is still SO LOW in getting measles, it’s not recommended. If an infant is exposed to measles, then we would immunize early because the risk is so increased in getting measles that it’s worth the small risk in it “blunting” the later immunizations to avoid an infection now.
Bottom line: talk with your pediatrician if any concerns but no need to change the vaccine schedule, even as we see more local cases and additional cases sporadically around the country. I’ll keep you posted if this changes.
Nice 1-page handout on measles and the vaccine for you for sharing!
MMR Vaccine Recommendations:
Routine vaccination
- 2-dose series at 12–15 months and again at 4–6 years
- Dose 2 may be administered as early as 4 weeks after dose 1.
Catch-up vaccination
- Unvaccinated children and adolescents: 2 doses at least 4 weeks apart
Special situations & International travel
- Infants age 6–11 months: 1 dose before departure; revaccinate with dose 2 at 12–15 months (12 months for children in high-risk areas) and dose 3 as early as 4 weeks later.
- Unvaccinated children age 12 months and older: 2-dose series at least 4 weeks apart before departure
- What should be done if someone is exposed to measles? Notification of the exposure should be communicated to a doctor. If the person has not been vaccinated, measles vaccine may prevent disease if given within 72 hours of exposure. Immune globulin (a blood product containing antibodies to the measles virus) may prevent or lessen the severity of measles if given within six days of exposure.
Linda Dillon says
Great reminders and review. I live in SE Michigan where we are also experiencing an outbreak. Can you share the ACIP reference about concerns MMR vaccination in 6-11mo olds can blunt subsequent immune response? We have families asking for an early vaccine dose in this age group due to the outbreak.
Wendy Sue Swanson, MD, MBE says
No official ACIP recommendation but the quote I provided in the blog post came from communications from Dept of Health (DOH) here in Washington state. I reached out to them to find out more about the sources of data for the concern about blunting subsequent MMR. Below I have included a list of some of the findings that supported the DOH and their ongoing decision not to encourage mass accelerated vaccination for all babies 6-12 months like they do when babies are traveling internationally where more dense and larger measles outbreaks are in process or have occurred. The shortest explanation is that even after they confirm that babies have lost most of their mom’s antibodies passed down to them during their in utero time, the infant’s response to a MMR vaccine during infancy is not as robust as after 1 year (3rd bullet point below) and that there is likely something about an infant’s immune development that occurs during 6-12 months of age that allows them to respond so well at a year of age. Further, when babies get the MMR during infancy it causes a less robust response to the shot later in life (at 1 year of age and later) and causes the vaccine protection not to be as robust and long-lasting. All this together make it hard to say babies should get immunized right now at 6-12 months….because thankfully, even though we have lots of measles cases, most are in small pockets and risk is fairly low for infants at large. The risk/benefit ratio for early immunization hasn’t yet tipped. This (could) change in the case of a horrible outbreak.
1. Reported “slower antibody decay for rebella, emphasizing the important of MMR1 vaccination during the ACIP recommended timeframe” (12-15 months). Seagle, E. E., Bednarczyk, R. A., Hill, T., Fiebelkorn, A. P., Hickman, C. J., Icenogle, J. P., Belongia, E., A., and McLean, H. Q.. (2018). Measles, mumps, and rubella antibody patterns of persistence and rate of decline following the second dose of the MMR vaccine. Vaccine 36 (2018) 818-826. https://doi.org/10.1016/j.vaccine.2017.12.075.
2. Authors reported lower antibody concentrations in cohorts given the first vaccine dose at 6 months of age and in the presence of passive immunities, but reported responses could be boosted by subsequent doses. They also reported “when infants received their first dose of vaccine at 6 months of age, humoral responses measured at 5-10 years of age were diminished compared with the responses of those vaccinated at 12 months of age. There is further discussion that “humoral immunity is not inhibited permanently by early immunization and can be boosted to high concentrations. Gans, H. A., Yasukawa, L. L., Sung, P., Sullivan, GB. DeHovitz, R., Audet, S., Beeler, J., and Arvin, A. M. (2015) JID 2013:207, 574-582. doi:10.1093/infdis/jis719
3. “Humoral immunity was deficient in 6-month-old infants given measles vaccine, even in in the absence of detectable passively acquired neutralized antibodies. Comparison of their responses with those of 9- and 12-month-old infants indicates that a developmental maturation of the immune response to measles may occur during the first year of life, which affects the immunogenicity of measles vaccine. Gans, H. A., Arvin, A. M., Galinus, J., Logan, L., DeHovitz, R., and Maldonado, Y. (1998). JAMA, August 12, 1998-Vol 280, No 6, 527-532.
KWu says
Same question as above: is there a citation for the bit on “administration of MMR below the age of 12 months has been associated with blunting of the immune response to subsequent doses”? Would be good to get a sense of how the blunting of the eventual immune response measures against the number of measles cases in the local area. Thank you!
Wendy Sue Swanson, MD, MBE says
see comment response above and let me know if I can provide anything further!
Gregory Burzynski says
In some children, the infection caused pneumonia and in a few, encephalitis (infection of the brain) and even death.If you are not sure if you or your children have been fully vaccinated against measles, talk with your doctor to see if anyone in your family needs to be vaccinated. Measles is very contagious and the virus can live for up to two hours on surfaces infected patients have touched or in the air where they may have coughed or sneezed. Very alarming. Timely post Dr. Swanson. Good reminders for all of us to take Measles outbreak seriously.
-Internist in Houston
Sofia Norton says
Thank you for the article. I’m quite concerned about the discussion on “humoral immunity is not inhibited permanently by early immunization and can be boosted to high concentrations.” Would this mean that infants who take in the MMR will still be susceptible to measles later on?
Holly Grand says
Thank you for the post! In regards to infants 6-12 months of age, does domestic flight travel warrant early vaccination? I know the CDC recommends vaccinating infants traveling internationally … does spending time at an international airport and/or flight with potentially foreign travels confer the same risk?