There’s new data out to support stronger recommendations for introducing peanuts during infancy. Like hemlines, it may seem like this data keeps changing. As time, the science and our understanding of risk unfolds we’ve seen shifts in advice about starting solids that have left many parents wondering what really is best when starting foods and wanting to decrease risk for food allergy.
Briefly, and in general, it’s best to start a variety of foods for your child during infancy, starting around 4 to 6 months of age. In fact its now believed that it may be protective to introduce things like wheat, egg, soy, fish, and peanuts even before a child takes their first step around a year of age. The 2013 recommendations (that exclude information about peanuts) are explained in this post, “When Should I start Baby Food?”
The recommendation to share diverse foods during infancy that includes fish and eggs may feel new to you. For example, when my babies were born (mid-2000’s) advice and consensus suggested that avoidance of peanuts until after a year of age was best — the thought that avoidance of peanut during critical development may be protective against severe allergy development. Now, concomitant with a doubling in food allergies, we face an utter and potentially embarrassing reality — perhaps medical advice and our work to improve allergy risk by restricting foods in infancy did just the opposite. Perhaps avoidance was exactly the wrong thing to do. Maybe we’ve engineered part of the problem.
This kind of advice can feel intense when raising children. “Do this, don’t do that, do this now, don’t do this now!” Doing the right thing is what we all want but doing right can remain elusive, especially when recommendations shift. I remember a fellow pediatrician questioning my eating a peanut butter sandwich while I was pregnant with my second son. She couldn’t believe I’d made that choice. At the time I remember not only feeling judged but a little terrified too. Perhaps I’d not take the data seriously enough? Oh goodness, I thought, as I diligently didn’t introduce “high allergy” foods until toddlerhood for my boys. Today I realize that wasn’t all that right either. It can feel like another hemline change for sure and yikes these sure are shorter skirts!
Fast forward 7 years to 2015. A New England Journal of Medicine study out this past month systematically evaluated risk for development of peanut allergy in children who were at higher risk for developing the allergy in the first place. And they started with infancy and introduced peanuts early in some of the babies. Researchers found if infants were introduced to peanuts early in life (between 4 and 11 months of age) their risk of peanut allergy at age 5 years significantly decreased.
The early introduction of peanuts significantly decreased the frequency of the development of peanut allergy among children at high risk for this allergy. ~ New England Journal Of Medicine
Before I detail the numbers from this study let me also acknowledge that this is a science thing yes, but its also a feeling thing too. As a culture we’re living with new compassion and smarts about food allergies as we protect those with life-threatening allergies. From the Teal Pumpkin Project at Halloween, to the nearly universal option for peanut-free zones at school lunch, to more compassionate birthday party policies all help. Allergy family experts have communities like FARE (Food Allergy Research & Education) that support parents, coaches and educators in staying up to date on the science. Vocal parents wed with mom-to-mom storytelling helps us all understand better. But no question as this data comes out children still suffer in an environment that isn’t entirely kind or necessarily deft at creating a safe, welcoming environment for eating with a food allergy. Restaurants still warn about “no guarantees” for safety and up to a 1/3 of children with food allergy report being bullied because of their allergy. Parents are rightly motivated and amped to avoid the diagnosis of food allergy in the first place as we work to contribute to these cultural transitions and prevent this challenge all together.
No question anxiety drives quite a bit of our parenting choices at times as we navigate the opportunities to protect our children. Often anxiety about rising numbers of children with allergies stifles parents to introduce new foods. Most of us have heard that peanut allergies have doubled in the past decade, with an estimated 400,000 school aged children in the US suffering from mild to severe reactions if exposed to an allergen. For many children peanut exposure can be life-threatening. And while peanut allergies develop early in life up to 20 percent of kids will thankfully outgrow them. Learning to reduce risk is what we’re all hoping for.
Infants At Risk For Peanut Allergy, NEJM Study
- Babies Included in Study: More than 600 British infants age 4 – 11 months-old were included in the study. Infants included were selected for the study after being deemed high-risk of developing peanut allergy. Risk for allergy in this case included an established egg allergy or significant eczema (a skin rash often seen in “allergic babies and children”).
- Four Groups of Babies: Four groups of infants were created. Two groups consisted of infants who showed sensitivity in their skin to peanut testing, the other two groups did not. Those with no skin sensitivity were further divided, some were fed peanuts starting as young as 4 months, the others not. The group of children reactive to peanut by skin were divided similarly — some got peanuts during infancy, the others were restricted and got none during early childhood. All children were then evaluated for peanut allergy at age 5 years.
- Results: Children who consumed peanuts starting during infancy were far less likely to be allergic to peanuts at age 5 years. Children with no skin reaction to peanuts were most protected: 13.7% of group that avoided peanuts tested positive for allergies while only 1.9% of the group that consumed peanuts tested positive for allergies at age 5. In children who initially had skin reactions to peanuts (98 of 640 infants) similar protection from eating peanuts was observed. Of those, 35% of children who avoided peanuts had a food allergy at 5 years while only 10% who ate peanuts throughout infancy and toddlerhood developed the allergy.
Researchers are quick to reiterate that this was a controlled study in a medical environment with children at increased risk for allergy. No question that this is new science and new discovery. If your child is at risk for peanut allergies, seek help from your pediatrician before giving your baby peanut foods (peanuts still a choking risk in toddlerhood and infancy!) or peanut butter in infancy. Researchers are also uncertain as to whether peanut allergies can develop when the regular feeding of peanuts (regulated by the study) stops. Ongoing evaluation will unfold.
The current American Academy of Pediatrics policy on food allergy introduction (revised in 2008) states there is insufficient evidence to support delayed introduction of potential food allergens to reduce the risk of developing allergies. This means holding back on foods during infancy isn’t recommended! We’re moving towards not waiting on any foods in late infancy and this data on peanuts is the beginning of understanding creating recommendations to start foods early.
Further know this about allergy testing: skin tests, the most common type of allergy testing, can sometimes create a false positive and don’t always properly portray the depth of the food allergy or a child’s tolerance of foods. You should always use skin and allergy blood tests together with life experience in determining your child’s allergy profile. If your child tested positive for a food allergy using a skin test, but you’d like to learn more about the severity of their allergy (or if there’s a chance the skin test misrepresents their tolerance) talk with your child’s doctor. The Seattle Children’s Food Allergy Challenge Clinic is a new treatment center for patients (ages 4 to 21) who have previously tested positive for severe food allergies to milk, eggs, peanuts, tree nuts or sesame seeds. Using a highly controlled protocol, the team can “challenge” these allergies by allowing a child to consume increasing amounts of a food to which they may be allergic while under the observation of trained medical staff. Staff at Seattle Children’s are highly experienced in treating anaphylaxis and are well qualified to perform these challenges so it can be a safe place to support your child and understand their allergy better. You can read more about the clinic here and I’ll post more from allergy experts in the months to come. Would love to include questions you may have.
B Gregory says
There should be no push to require vaccines because only the pharmaceutical companies know all the ingredients – which is why vaccines are causing the peanut allergy epidemic and most doctors don’t realize it. Peanut oil must be labeled in food but not pharmaceuticals. Pharmaceutical companies can self-affirm GRAS ingredients which do not need to be listed as an ingredient and become a protected trade secret, protected by international law. Nothing is ever submitted to the government. Canadian laws and American are about the same. The oil used in pharmaceuticals is highly refined so most peanut allergic people can usually EAT it and not have a problem. (Severely allergic people could still die). When the oil is injected along with an aluminum adjuvant, that tiny bit of peanut protein creates a peanut allergy in the unlucky kid who got it. It is not enough protein to contaminate every shot just a few in the batch.
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Certain unrefined oils can contain significant quantities of protein, as high as 300 micrograms per gramFootnote2,Footnote3 (µg/g = parts per million). In contrast, highly refined oils contain very little protein, with published data showing low µg/g values or lower.
In Canada, sections B.01.009 (4) and B.01.010 of the Food and Drug Regulations require that whenever peanut oil is present as an ingredient, or component of an ingredient, in a food, the source of the oil, “peanut”, must always be identified. The enhanced allergen labelling regulations do not change this requirement and therefore all peanut oil, whether highly refined or not, will have to identify its source in all cases.
https://www.hc-sc.gc.ca/…/oil-refined-huile-raffinees…
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Notice that it only says must be labeled in FOOD.
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Self-affirmed GRAS under fire again as PEW highlights ‘loophole that appears to have swallowed the law’
By Elaine Watson, 27-Jul-2012
There are serious weaknesses in a system that allows firms to self-affirm the safety of food ingredients without the approval or knowledge of regulators, according to researchers conducting a probe into the nation’s food additives law.
https://www.nutraingredients-usa.com/…/Self-affirmed…
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And the same self affirmed GRAS regulation is allowing pharmaceutical companies to secretly decide on ingredients they use in vaccines and other pharmaceuticals.
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Under U.S. law, an excipient, unlike an active drug substance, has no regulatory status and may not be sold for use in food or approved drugs unless it can be qualified through one or more of the three U.S. Food and Drug Administration (FDA) approval mechanisms that are available for components used in food and/or finished new drug dosage forms.
These mechanisms are:
1. determination by FDA that the substance is “generally recognized as safe” (GRAS) pursuant to Title 21, U.S. Code of Federal Regulations, Parts 182, 184 or 186 (21 CFR 182, 184 & 186);
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And, yes, excipients are part of vaccines:
“Many regulatory agencies, in addition to defining an adjuvant based on its immune-enhancing biological activity, provide a regulatory and/or legal classification for the adjuvant component of a vaccine (e.g., excipient, active ingredient or constituent material).”
https://www.who.int/…/ADJUVANTS_Post_ECBS_edited_clean_Guide…
E Canfield says
If you are allergic to any component in a vaccine, you are medically exempt from that vaccine. Not even the most ardent pro-vaxxer recommends forcing someone with a medical exemption. And Dr. S. was not advocating forcing anyone to be vaccinated, ‘though she surely recommends it to virtually all her patients and their parents.
Anecdotally, my 7 year old nephew and his grandfather are both allergic to peanuts, and fully up-to-date on vaccines and boosters. Except for Dad’s smallpox vaccine scar, neither has had a reaction to any immunization worse than a sore spot that goes away in a little bit.
Jennifer says
Wow, that certainly is a lot of information. And all of it seems to ignore what this article is about.
I didn’t know that I was supposed to wait until age 2 to give my son peanut butter, I thought I had read that after age 1 any food was ok. So I may have given him some of those peanut butter sandwich crackers, once or twice, until I read that it was recommended to wait until after age 2. So on his 2nd birthday, I sat him in his high chair and made him peanut butter toast, thinking he was in for a real treat! He was hesitant to eat it, but took a lick, and his eyes started watering, he began coughing, broke out in hives, and cried. The nurse on the phone told me to get him some Benadryl, and make an appointment with an allergist.
He tested positive for peanut allergy, and I’ve always felt guilty for giving him PB crackers before he was ready. Until reading this tonight.
Recently I read another post on CHILD about research into probiotic replacement therapy for kids with allergies, suggesting that the bodies’ natural bacteria that breaks down the allergen’s proteins has been killed off by antibiotics at some point. It pointed out that every food that goes into our bodies is a foreign substance capable of causing an immune over-response (which is what an allergy is) and that it’s the plethora of bacteria in our system that enables us to safely eat anything at all. They are testing to see if replacing some strains of bacteria gets rid of the allergic response.
While it is convenient to blame everything on vaccines, vaccine use in recent years had declined but the allergies are on the incline. Doesn’t add up.
Winston Yeung says
Thanks for this. It sounds like this replicates the oral immunotherapy protocol put forth by Dr. Kari Nadeau a couple of years ago. However, I’m having a hard time finding anything in the literature that sheds any light on the introduction of peanuts to older children, as opposed to infants. I wonder if there is a certain age range where the sensitivity to peanuts, or other allergens for that matter, is “set” in the body, and thus is harder to desensitize.
Wendy Sue Swanson, MD, MBE says
Hi Winston,
I think what you wonder (about critical periods of sensitization, etc) sits at the center of interest for this work; this interest is precisely what some of this new research is uncovering — periods of critical time for introduction of potential allergic triggers. The difference in this study from Dr Nadeau’s work (as I understand it) is that this study systematically evaluated ways to prevent allergies in the first place as opposed to reversing hypersensitivity thereafter with immunomodulation. Here’s more on Dr Nadeau’s lab: https://nadeaulab.stanford.edu/
This is a hugely important study in part because of the dramatic results (80% reduction in allergy risk with early, infantile introduction of peanuts) — check out Dr Fauci’s comment in the NIH press release:
“Food allergies are a growing concern, not just in the United States but around the world,” said NIAID Director Anthony S. Fauci, M.D. “For a study to show a benefit of this magnitude in the prevention of peanut allergy is without precedent. The results have the potential to transform how we approach food allergy prevention.”
https://www.nih.gov/news/health/feb2015/niaid-23.htm
Brittany Hannon says
I am curious if the introduction to peanuts in infants who have tested positive for allergy should happen ONLY in an allergist’s office? I can’t imagine giving the child peanuts at home would be a good idea if they test positive for the allergy, is that correct?